埃塞俄比亚HIV-TB同时感染患者的死亡率和预测因素:系统性审查和元分析
Wubet Tazeb Wondie1, Chalachew Adugna Wubneh2, Bruck Tesfaye Legesse3
1Department of Pediatrics and Child Health Nursing, College of Health Sciences and Referral Hospital, Ambo University, Ambo, Ethiopia.
PloS one
|January 6, 2025
概括
在埃塞俄比亚,18.42%的艾滋病毒和结核病联合感染的患者死亡. 死亡率的关键预测因素包括贫血,对ART的不良坚持,不服用co-trimoxazole预防疗法和肺外结核病.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 传染性疾病 传染性疾病
背景情况:
- 在撒哈拉以南非洲,特别是埃塞俄比亚,艾滋病毒-结核病联合感染是造成重大公共卫生问题的.
- 关于埃塞俄比亚HIV-TB同时感染患者的死亡率的先前研究产生了不一致的结果.
- 缺乏全面的死亡率估计和预测分析.
研究的目的:
- 确定埃塞俄比亚艾滋病毒-结核病同时感染患者的综合死亡率.
- 确定与该人口死亡率相关的显著预测因素.
- 为管理艾滋病毒-结核病共感染的公共卫生战略提供信息.
主要方法:
- 在多个数据库和谷歌学者中进行了系统的文献搜索.
- 包括观察性研究报告埃塞俄比亚HIV-TB同时感染患者的死亡率.
- 进行了随机效应模型,异质性评估,子组,敏感性和出版偏差分析的元分析.
主要成果:
- 在886项已识别的研究中,有37项被纳入了元分析.
- 在HIV-TB同时感染的患者中,合并死亡率比例为18.42%.
- 死亡的重要预测因素包括贫血,对ART的不良坚持,不服用co-trimoxazole预防疗法和肺外结核病.
结论:
- 在埃塞俄比亚,艾滋病毒-结核病同时感染的患者中有很大一部分 (18.42%) 死亡.
- 针对贫血,ART坚持,co-trimoxazole预防疗法和肺外结核病管理的干预措施至关重要.
- 建议利益关方加强协作性艾滋病毒-结核病服务.
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