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Updated: Jun 12, 2026

Live Imaging Followed by Single Cell Tracking to Monitor Cell Biology and the Lineage Progression of Multiple Neural Populations
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在发育和受伤的脊髓中表征原生细胞:从单核转录组学和谱系追踪的见解

Qi Zhang1, Xianming Wu1, Yongheng Fan1

  • 1State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100080, China.

Proceedings of the National Academy of Sciences of the United States of America
|January 6, 2025
PubMed
概括

成年人脊髓中含有具有多血统潜力的星球细胞. 这些细胞在受伤后可以转化为寡 dendrocytes,为脊髓修复研究提供新的途径.

关键词:
星球细胞是星球细胞.谱系追踪 谱系追踪 谱系追踪单核RNA测序的一个核.脊髓损伤导致的脊髓损伤通过转差异化转化.

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Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...