开发和评估用于质子疗法监测的内束PET系统
Qiuhui Ma1, Dengyun Mu2, Ruilin Zhang2
1The School of Artificial Intelligence and Automation, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Physics in medicine and biology
|January 6, 2025
概括
这项研究开发了一种双头内束正子发射断层扫描 (PET) 系统,用于实时监测质子疗法. 该系统展示了高计数率和精确的范围监控在光束在操作期间.
科学领域:
- 医学物理 医学物理
- 核医学就是核医学.
- 放射治疗技术 放射治疗技术
背景情况:
- 射线正子发射断层扫描 (PET) 提供了实时质子疗法监测的潜力.
- 在Beam-on操作期间的高辐射爆发对PET系统性能构成重大挑战.
研究的目的:
- 开发和评估一个双头内束PET系统,用于实时的质子疗法监测.
- 评估系统在高辐射条件下的性能及其对范围验证的能力.
主要方法:
- 开发了一种使用Plug&Imaging (PnI) 检测单元与-伊氧晶体阵列的双头内光束PET系统.
- 每个PNI单元都有6x6的晶体阵列与光倍增器相结合.
- 使用幻象和时间动态鼠标成像评估性能,并使用PMMA幻象上的质子束测试范围监测.
主要成果:
- 在144.9 MBq的单次计数率达到了48 Mcps,绝对灵敏度为2.717%和空间分辨率为~2.6 mm FWHM.
- 成功地在Derenzo幻影中解决了2.0毫米的棒,并证明了小鼠的代谢成像.
- 在PMMA幻影中监测了130 MeV的质子束范围,误差小于1毫米,即使模拟范围转移.
结论:
- 开发的光束内PET系统具有高计数率的功能,适合光束操作.
- 该系统展示了有效的实时范围监测,这对于质子疗法验证至关重要.
- 这项技术在推进生物学引导的质子疗法和实时范围验证方面具有重大潜力.
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