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针对基于细胞和基因的疗法的目标产品概况,以实现治愈艾滋病毒

Sharon R Lewin¹, Cathy Bansbach², Dominic Kemps³

¹Department of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.

The lancet. HIV

|January 6, 2025

概括

开发用于治愈HIV的细胞和基因疗法需要明确的目标. 这一目标产品概况 (TPP) 概述了这些创新的艾滋病毒治疗方法的最小和最佳特性.

科学领域:

免疫学免疫学免疫学
病毒学病毒学
生物技术是生物技术.
公共卫生公共卫生

背景情况:

有效,安全,可扩展,负担得起,可访问和可接受的艾滋病毒治疗仍然是全球卫生优先事项.
细胞和基因疗法为实现功能性艾滋病毒治愈提供了越来越多的可能性,定义为持久的无抗逆转录病毒病毒控制.
开发这种先进疗法需要明确定义的产品特性.

研究的目的:

建立针对基于细胞和基因疗法的产品的目标产品配置文件 (TPP),旨在治愈艾滋病毒.
定义ex-vivo和in-vivo治疗方法的最小和最佳特征.
促进多方利益相关者就艾滋病毒治疗产品的发展目标达成共识.

主要方法:

一个涉及临床专家和民间社会代表的多方利益相关者共识过程.
讨论并就治疗艾滋病毒治疗的目标产品特征达成协议.
考虑不同的观点,包括来自低收入和中等收入国家的观点.

主要成果:

他们就HIV治疗产品开发的最佳目标达成了总体协议.
对于所有参数,特别是对体外疗法,由于其复杂性,未能就最小目标达成共识.
该TPP为可接受和一致的HIV治疗干预措施的发展提供了一个框架.

结论:

开发的TPP是推动细胞和基因疗法的关键指南,旨在治愈艾滋病毒.
利益相关者参与产品配置文件的定义对于开发临床医生和患者可以接受的疗法至关重要.
需要定期更新TPP,以反映艾滋病毒治疗研究的不断变化.

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