相关实验视频

Updated: Jun 3, 2025

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

产前接触多重金属对婴儿神经发育的影响:一种多统计方法

Xiruo Kou¹, Meritxell Pallejà Millán², Josefa Canals³

¹Nutrition and Mental Health (NUTRISAM) research group, Universitat Rovira i Virgili, 43204 Reus, Spain; Institut d'Investigació Sanitaria Pere Virgili (IISPV), 43204 Reus, Spain.

Environmental pollution (Barking, Essex : 1987)

|January 6, 2025

概括

产前接触和等重金属会对婴儿的神经发育产生负面影响,特别是语言技能. 这项研究突出了金属混合物对早期大脑发育结果的联合影响.

科学领域:

环境健康环境健康
神经科学是一个神经科学.
发育儿科发育儿科

背景情况:

产前接触重金属是胎儿神经发育的已知危险因素.
多重金属对婴儿神经发育的综合影响尚不清楚.
之前的研究表明,在重金属暴露和神经发育结果之间的统计学关联方面,存在不一致的发现.

研究的目的:

研究产前暴露于 (Cd), (Ni), (Hg) 和 (Pb) 对婴儿神经发育的联合影响.
在评估这些关联时,比较各种统计模型的性能.
确定有助于不利神经发育结果的特定重金属.

主要方法:

研究包括400对母婴对.
在怀孕12周时,对母亲的尿样进行重金属分析.
婴儿神经发育在40天后使用贝利婴幼儿发育量表进行评估.
统计分析包括通用增量模型 (GAM),限制立方线 (RCS) 的多变量线性回归 (MLR),贝叶斯核机器回归 (BKMR) 和加权量子总和 (WQS) 回归.

主要成果:

GAM确定了与认知尺度和表达语言之间的显著线性关联.
MLR证实了与认知尺度和表达语言之间的负相关性.
RCS显示了和语言尺度之间的非线性关联.
WQS回归表明金属混合物对表达性语言有显著的不利影响,其中和是主要贡献者.

结论:

产前接触重金属混合物,包括和,会对婴儿的神经发育产生不利影响.
语言发育似乎特别容易受到怀孕期间重金属暴露的影响.
不同的统计模型为重金属混合物和神经发育之间的复杂关系提供了不同的见解.

关键词:

贝叶斯核机器回归贝叶斯核机器回归这是一种重金属,重金属.金属混合物金属混合物多重污染物多种污染物神经发育神经发育权重的量化数量总和.

更多相关视频

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Published on: March 6, 2018

Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays

Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays

Published on: April 26, 2018

相关概念视频

Teratogenicity

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...

Attention-Deficit/Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....

Types of Toxins

Types of Toxins

Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...