相关实验视频

Updated: Jun 3, 2025

Author Spotlight: Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator

Author Spotlight: Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator

Published on: May 19, 2023

阿迪波斯ZFP36可以防止饮食引起的肥胖和胰岛素抵抗

Yang Hu¹, Jinghan Hai¹, Yun Ti¹

¹State Key Laboratory for Innovation and Transformation of Luobing Theory, Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China.

Metabolism: clinical and experimental

|January 6, 2025

概括

脂肪ZFP36蛋白在肥胖症中是下调的. 缺乏脂肪ZFP36通过影响脂肪细胞大小和关键代谢途径,加剧了饮食引起的肥胖和胰岛素抵抗.

科学领域:

代谢障碍代谢障碍代谢障碍
肥胖研究的研究.
分子生物学分子生物学

背景情况:

肥胖是一个全球性的健康问题.
ZFP36是一种RNA结合蛋白,调节生理过程.
脂肪ZFP36在肥胖和胰岛素抵抗中的作用尚不清楚.

研究的目的:

研究脂肪ZFP36在肥胖中的作用.
为了确定ZFP36是否能防止饮食引起的肥胖.
阐明ZFP36在代谢调节中的分子机制.

主要方法:

在肥胖者和小鼠中分析了ZFP36的表达.
生成脂肪特异性的ZFP36淘汰赛 (ZFP36^AKO) 鼠标.
接受高脂肪饮食 (HFD) 的小鼠和评估的代谢参数.
利用基因阵列测定和体外/体外研究来探索分子途径.

主要成果:

在肥胖个体和小鼠的脂肪组织中,ZFP36的表达下调.
ZFP36^AKO小鼠表现出对HFD诱导的肥胖,胰岛素耐药性和葡萄糖不耐受性的敏感性增加.
在ZFP36^AKO小鼠中,肥胖与脂肪细胞缩和PLIN1,ATGL和HSL的表达减少有关.
发现ZFP36抑制了RNF128表达,这是Sirt1.1的负调节者.

结论:

脂质ZFP36在饮食引起的肥胖中起着重要作用.
确定了一种涉及肥胖的新型ZFP36/RNF128/Sirt1信号通路.
建议ZFP36作为肥胖和相关代谢障碍的潜在治疗标.

关键词:

肥胖的是一种脂肪.氧气过低是因为缺氧.脂质溶解脂质溶解是一种肥胖问题肥胖问题第128章没有RNF 在Sirt1上 ZFP36 ZFP36 的时间表.

更多相关视频

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

Published on: June 3, 2016

Isolation and Differentiation of Stromal Vascular Cells to Beige/Brite Cells

Isolation and Differentiation of Stromal Vascular Cells to Beige/Brite Cells

Published on: March 28, 2013

相关概念视频

Cell Specific Gene Expression

Cell Specific Gene Expression

Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...

Obesity

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...