儿科功能性腹痛疾病的流行病学:一个元分析
Nicolaas Koen Vermeijden1,2,3,4, Leilani de Silva5, Supun Manathunga6
1Pediatric Gastroenterology, Hepatology and Nutrition, Emma's Children Hospital, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
功能性腹部疼痛障碍 (FAPDs) 影响全球超过11%的儿童,女孩的发病率更高. 压力和焦虑等心理因素与FAPD患病率的增加有关.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 流行病学 流行病学
- 儿童心理学 儿童心理学
背景情况:
- 功能性腹部疼痛障碍 (FAPDs) 是儿童常见和使人虚弱的疾病.
- 全球FAPD的流行率和变异仍然不完全理解.
研究的目的:
- 估计在4-18岁儿童中FAPD的全球流行率.
- 根据诊断标准,地理位置,性别和年龄分析流行率的变化.
- 确定最常见和最不常见的FAPD类型.
主要方法:
- 流行病学研究的系统审查和元分析.
- 搜索了多个数据库 (Medline,Embase,CINAHL,PsycInfo,Cochrane) 截至2024年10月.
- 包括66项研究,超过20万名参与者,使用罗马标准进行诊断.
主要成果:
- 全球FAPD的综合流行率为11.7%,刺激性肠综合征是最常见的类型.
- 患病率因诊断标准 (罗马III与罗马IV) 不同,女孩的患病率高于男孩.
- 没有发现基于年龄的显著差异,但亚洲的患病率高于欧洲和北美.
结论:
- FAPD影响全球9分之一的儿童.
- 在女孩中更高的患病率和与心理压力因素的关联凸显了有针对性的干预措施的需要.
- 需要进一步的研究来解决语言限制和非洲人代表不足等局限性问题.
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