法莫蒂丁对肺动脉高血压结果的影响:一项随机对照试验
Peter J Leary1, Samuel G Rayner2, Kelley R H Branch3
1Division of Pulmonary, Critical Care, and Sleep Medicine, University of Washington, Seattle, WA; Department of Epidemiology, University of Washington, Seattle, WA.
在一项为期24周的试验中,法莫蒂丁并没有改善肺动脉高血压 (PAH) 患者的结局. 这项研究表明,famotidine不是推用于PAH的辅助疗法.
科学领域:
- 心脏病学 心脏病学
- 肺部医学 肺部医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 右心室适应对于肺动脉高血压 (PAH) 的结果至关重要.
- 缺乏针对PAH右心室的向治疗方法.
- 在心力衰竭中,H2受体对抗性被探索为心肌焦点战略.
研究的目的:
- 为了确定H2受体对抗剂,特别是famotidine,改善诊断为PAH的患者的临床结果.
- 评估famotidine作为PAH治疗辅助疗法的疗效.
主要方法:
- 这是一项为期24周的随机,双面膜,安慰剂对照试验,涉及80名PAH患者.
- 主要结局:6分钟步行距离 (6MWD) 的变化.
- 二次结局:B型尿素水平,NYHA功能类,心声录像RV参数,生活质量和PAH护理升级.
主要成果:
- 在 famotidine 和安慰剂组之间6MWD没有显著差异.
- 法莫蒂丁手臂显示6MWD (-17.0m) 的减少与安慰剂手臂 (4.7m) 的增加相比,P=0.24.
- 在二次终点上没有观察到差异; famotidine 耐受性很好,安全性概况相似.
结论:
- 日常使用每天20毫克的法莫蒂丁不支持作为PAH的辅助治疗.
- 来自REHAB-PH试验的研究结果表明,与甲基胺相关的PAH患者不应该被排除在临床试验之外.
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