肠道微生物群:对抗多种疾病和生物转换的Panax notoginseng理解的新关键
Yueting Mo1, Xiyuan He1, Hao Cui2
1Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Journal of ethnopharmacology
|January 6, 2025
概括
帕纳克斯诺托金生调节肠道微生物群以改善健康并增强自身的生物活性. 这种草药促进有益的细菌,并转化其化合物,以获得更好的吸收和治疗效果.
科学领域:
- 草药和微生物学 草药和微生物学
- 药理学和肠道健康 药理学和肠道健康
背景情况:
- 帕纳克斯诺托金森 (Panax notoginseng) 是一种传统的草药,具有多种治疗用途,包括抗炎和循环功效.
- 它的有效性在诸如肥胖,肝脏疾病,结肠炎和阿尔茨海默病等疾病中得到了注意.
研究的目的:
- 审查Panax notoginseng和肠道微生物群之间的复杂关系.
- 阐明Panax notoginseng药理作用及其生物转化背后的双向作用和机制.
主要方法:
- 从1998年到2024年对数据库 (PubMed,CNKI,Google Scholar) 进行系统的文献搜索.
- 包括原始研究,临床试验和Panax notoginseng的评论.
- 针对"肠道微生物群"",肠道微生物群"和"肠道生物转化"的关键词搜索.
主要成果:
- 帕纳克斯诺托金生促进有益的肠道细菌 (如乳酸菌,双菌,阿克尔曼西亚),同时减少有害的细菌.
- 肠道微生物群通过脱糖化将Panax notoginseng saponins (PNS) 转化为更多的生物活性化合物 (PPT,PPD),克服了低生物可用性.
结论:
- 肠道微生物群在Panax notoginseng的治疗作用中起着至关重要的作用.
- 这种相互作用对于治疗代谢,肝脏,神经,脏和血管疾病以及大肠炎至关重要.
- 微生物生物介导的生物转化增强了Panax的整体疗效.
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