在质瘤中,ALKBH5通过m6A-YTHDC1依赖的机制促进瘤的进展

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Updated: Jun 3, 2025

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Chenyang Wang1, Ningbo Xu2, Xiangyang Zhong3

  • 1Department of Neurosurgery Center, The National Key Clinical Specialty, The Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular Disease, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, The Neurosurgery Institute of Guangdong Province, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China; Department of Geriatrics, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, 510282, China.

Cancer letters
|January 6, 2025
PubMed
概括

AlkB同源5 (ALKBH5) 通过降低分叉盒蛋白O1 (FOXO1) 的稳定性来促进质瘤. 准ALKBH5/FOXO1通路为结质瘤提供了潜在的新疗法.

关键词:
在 ALKBH5H5 中这就是FOXO1的意义.质母细胞瘤 (glioblastoma) 是一个恶性进展的恶性进展这是一种β-catenin.

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