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Updated: Jun 3, 2025

Modification and Functionalization of the Guanidine Group by Tailor-made Precursors
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Modification and Functionalization of the Guanidine Group by Tailor-made Precursors

Published on: April 27, 2017

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伦卡西瓜特通过必要的基因激活可溶性甘烯酸环酶,这对于血红素结合和氧化激活至关重要

Theresa Wittrien1, Anne Rühle1, Christin Elgert1

  • 1Department of Pharmacology, Toxicology and Clinical Pharmacy, University of Braunschweig - Institute of Technology, Germany.

Biochemical pharmacology
|January 6, 2025
PubMed
概括

像runcaciguat这样的第二代可溶性瓜尼利环酶 (sGC) 激活剂,需要histidine 105来激活,与早期的药物不同. 这一发现需要重新评估使用histidine突变体的sGC研究和药物开发.

关键词:
在中国,它被认为是中国人.酶结合研究的研究.方法评价方法评价方法评价拉纳卡西古瓦特的情况.sGCGC 公司sGC激活器的使用方法

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