在子宫内膜癌中,Ki-67表达和一种新的 perfusion MRI 生物标志物扩散衍生血管密度 (DDVD) 之间存在很高的相关性
Fang Wang1, Yafei Wang1, Lisha Qi2
1Department of Radiology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy Tianjin, Tianjin, China.
Magnetic resonance imaging
|January 6, 2025
概括
扩散衍生的血管密度 (DDVD) 有效地表征子宫内膜癌 (EC) 微血管. 较高的DDVD值与Ki-67增多和侵略性瘤类型的增加相关,有助于预治疗风险评估.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 医疗成像医学成像
背景情况:
- 子宫内膜癌 (EC) 微血管表征对于治疗规划至关重要.
- 扩散衍生血管密度 (DDVD) 为瘤微血管形成提供了一个潜在的成像生物标志物.
研究的目的:
- 评估扩散衍生的血管密度 (DDVD) 在表征子宫内膜癌 (EC) 微血管中的可行性.
- 探索DDVD值,Ki-67扩散状态和EC中的组织学类型之间的相关性.
主要方法:
- 扩散衍生容器密度 (DDVD) 使用公式DDVD ((b0b20) = Sb0/ROIarea0 - Sb20/ROIarea20.) 来计算.
- 统计分析包括ICC,独立样本t测试,曼·惠特尼U测试和对81名EC患者的ROC曲线分析.
主要成果:
- 与肌体相比,EC显示了较低的DDVD(b0b20) 值 (34.9与65.3相比,P < 0.001).
- 较高的DDVD值与高的Ki-67增殖 (44.17对16.08,P<0.001) 和攻击性的组织学类型 (47.92对30.77,P=0.002) 相联系.
- ROC分析显示,Ki-67表达的AUC为0.842,组织类型为0.771,表明DDVD的辨别能力.
结论:
- 扩散导出的血管密度 (DDVD) 作为一个有价值的成像标志物用于基-67的扩散和组织学攻击性在EC.
- 对于子宫内膜癌患者来说,DDVD可以帮助预治疗风险分层.
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