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相关概念视频

RNA Structure01:23

RNA Structure

Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
DNA Base Pairing02:27

DNA Base Pairing

Erwin Chargaff’s rules on DNA equivalence paved the way for the discovery of base pairing in DNA. Chargaff’s rules state that in a double-stranded DNA molecule,
DNA Topoisomerases02:02

DNA Topoisomerases

Topoisomerases are enzymes that relax overwound DNA molecules during various cell processes, including DNA replication and transcription. These enzymes regulate positive and negative DNA supercoiling without changing the nucleotide sequence. DNA overwinding in a clockwise direction results in positively supercoiled DNA, whereas underwinding in a counterclockwise direction produces negatively supercoiled DNA.
Types and Mechanism of action
Topoisomerases are divided into two main types.  Type I...
RNA Structure01:23

RNA Structure

Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
RNA Structure01:19

RNA Structure

The basic structure of RNA consists of a string of ribonucleotides attached by phosphodiester bonds. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA) involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three...
Nucleic Acid Structure01:25

Nucleic Acid Structure

The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA has a double-helix structure. The...

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相关实验视频

Updated: Jun 22, 2026

Single-molecule Manipulation of G-quadruplexes by Magnetic Tweezers
08:28

Single-molecule Manipulation of G-quadruplexes by Magnetic Tweezers

Published on: September 19, 2017

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结结的年代记:揭开G-四重复的幕

Himanshi Sharma1, Rohini Garg1

  • 1Centre of Excellence in Epigenetics, Department of Life Sciences, Shiv Nadar Institution of Eminence, Gautam Buddha Nagar, India.

Critical reviews in biotechnology
|January 6, 2025
PubMed
概括

G-四重复结构 (GQSes) 对于DNA和RNA的基因调节至关重要. 了解GQSes为植物生物技术的进步提供了潜力.

科学领域:

  • 分子生物学分子生物学
  • 遗传学 遗传学 是一个
  • 生物技术是生物技术.

背景情况:

  • G-四重复结构 (GQSes) 是参与基本细胞过程的非正规核酸结构.
  • 它们普遍存在于基因调节区域,如促进体和5'-UTR,影响基因表达.
  • 无论是DNA还是RNA都可以形成GQSes,表现出独特和共同的特征.

研究的目的:

  • 审查GQSes在整个基因组中的多样性功能.
  • 探索DNA和RNA之间的相似性和差异 GQSes.
  • 突出GQSes在植物开发和生物技术中的作用.

主要方法:

  • 关于GQS功能和检测的文献综述.
  • 用GQSes对蛋白质相互作用的分析.
  • 在植物基因调节中探索GQSes.

主要成果:

  • 在复制,转录和翻译中,GQSes发挥着重要的作用.
  • 特定的蛋白质与GQSes相互作用,调节它们的功能.
  • GQSes与植物发展有关,可以用于生物技术.

结论:

关键词:
在DNA中,G-四重复性存在.在UTRs中的G-四复合体.在促进体中的G-四复合体.在GQS中,HeliCase是GQS的直升机.在RNA G-四重复合体中.基因调节 基因调节 基因调节确定G-四重复合体的鉴定

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Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes
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  • GQSes是DNA和RNA中基因表达的多功能调节者.
  • 了解GQSes及其相互作用蛋白质是其功能性利用的关键.
  • GQS代表了促进植物生物技术发展的有希望的监管开关.