可以使用GastroPanel作为选工具来选择晚期缩性胃炎患者进行胃镜检查吗? 一个前性的临床验证研究
Cinzia Papadia1,2, Laura Marelli3, Eleanor Wood3
1Gastroenterology, Barts Health Trust, London, UK cinzia.papadia@nhs.net.
BMJ open gastroenterology
|January 6, 2025
概括
GastroPanel可以准确地识别腹不良患者中度至重度的缩性胃炎. 这种血液测试有助于区分那些需要进一步调查胃腺癌 (GAC) 的个人.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 生物标志物研究 生物标志物研究
背景情况:
- 胃腺癌 (GAC) 在英国的5年生存率很低.
- 慢性缩性胃炎 (AG) 是GAC的前体.
- 准确识别中度至严重的AG对于风险分层至关重要.
研究的目的:
- 为了评估GastroPanel的诊断性能,以识别在消化不良患者中中度至严重的缩性胃炎 (AG).
- 评估 GastroPanel 作为一种非侵入性分类工具的实用性.
主要方法:
- 一项前性,单中心的诊断准确性研究,涉及324名消化不良患者.
- 胃镜检查与活检和组织学 (更新的悉尼系统) 作为参考标准.
- 血样本的GastroPanel分析测量了pepsinogen I (PGI),PGII,胃素-17,以及H. pylori IgG. 的含量.
主要成果:
- GastroPanel显示,与更新的悉尼系统分类的总体一致性为90%.
- 权重卡帕 (κw) 表示实质性协议 (0.828).
- 接收器操作特征 (ROC) 分析表明,在识别体 AG (AUC分别为0.840和0.960) 中,PGI和PGI/PGII比率的高准确性.
结论:
- GastroPanel是一种可靠的非侵入性测试,用于消化不良的分类.
- 它可以有效地区分患有中度至重度体缩性胃炎的患者,这些患者患GAC的风险更高.
- 这有利于低风险个体的保守管理,并引导高风险患者进行进一步评估.
更多相关视频
相关概念视频
01:28Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
88
Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
88
01:29Endoscopic Procedures I: Esophagogastroduodenoscopy
64
An Esophagogastroduodenoscopy (EGD) is a diagnostic procedure in which an endoscopist uses a flexible, lighted endoscope to visualize the upper gastrointestinal (GI) tract. The procedure includes visualizing the oropharynx, esophagus, stomach, and the first part of the small intestine, the duodenum.
During an EGD, the endoscope can be used to:
During an EGD, the endoscope can be used to:
64
01:23Gastritis III: Clinical Manifestations and Management
150
The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
150
01:29Gastroesophageal Reflux Disease II: Clinical Features and Management
54
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
54
01:26Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy
48
This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
48
01:26Endoscopic Procedures V: ERCP
79
Endoscopic Retrograde Cholangiopancreatography (ERCP) is a diagnostic procedure that combines endoscopy and fluoroscopy to diagnose and treat conditions related to the bile ducts, pancreatic ducts, and gallbladder. This procedure is beneficial for identifying and addressing blockages, gallstones, strictures, and tumors within the biliary or pancreatic systems. ERCP is both diagnostic and therapeutic, offering the ability to visualize and treat identified problems in one session.
Patient...
Patient...
79