根据使用策略,坚持使用印布里尔/阿姆洛迪平/阿托瓦斯塔丁组合剂
Gabriella Morabito1,2, Federico Rea1,2, Giovanni Corrao3
1National Centre for Healthcare Research & Pharmacoepidemiology, at the University of Milano-Bicocca Milan, Italy.
European heart journal. Quality of care & clinical outcomes
|January 6, 2025
概括
多种药丸 (单片药丸) 显著改善了药物坚持,并降低了医疗保健费用,而不是使用单独的药丸用于林多普里尔,安洛迪平和阿托瓦斯塔丁. 这支持在现实世界心血管治疗中使用多药丸.
科学领域:
- 心血管医学 心血管医学
- 药理学 药理学是指药理学的学科.
- 医疗保健服务研究 医疗服务研究
背景情况:
- 药物坚持对于控制心血管疾病至关重要.
- 固定剂量组合药丸 (多种药丸) 旨在简化治疗方案.
- 在临床实践中,比较多药片与单独药片的坚持是必不可少的.
研究的目的:
- 为了比较治疗的坚持性,在一个林多普林/阿姆洛迪平/阿托瓦斯塔丁多药丸和相同的药物在单独的药片配方之间.
- 评估多药药对心血管相关医疗保健费用的影响.
主要方法:
- 一项使用来自意大利伦巴第的医疗保健利用数据的现实研究.
- 1110名服用多种药丸的患者与1110名服用单独药丸的患者进行了匹配.
- 坚持测量为覆盖日数的比例 (PDC>75%的高坚持,<25%的低坚持).
- 基于组的轨迹建模评估了坚持动态; 逻辑-二项式回归分析了坚持风险比率.
主要成果:
- 在60%的多药丸使用者中观察到高坚持,而在单独药丸使用者中只有18%.
- 与单个药丸使用者 (37%) 相比,多药丸使用者 (5%) 的低坚持率明显较低.
- 多药丸使用增加了高坚持率的3.29倍,并降低了低坚持率的风险 (RR=0.13).
- 多药丸组的医疗费用较低 (676欧元对1068欧元).
结论:
- 在现实环境中,与单独的药丸相比,多药丸显著提高了药物坚持.
- 多种药丸的使用与心血管相关的医疗保健费用降低有关.
- 这些发现支持将多种药物纳入心血管疾病管理的临床指南.
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