身体质量指数与甲状腺结节的联系轨迹在中国的年轻成年期
Hang Yan1, Su Yan1,2, Jingfeng Chen1
1Health Management Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Scientific reports
|January 6, 2025
概括
显著的体重指数 (BMI) 轨迹显著影响甲状腺结节 (TN) 风险. 在成年早期 (27-47岁) 控制BMI增长对于预防TN流行至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 身体质量指数 (BMI) 轨迹可能会影响甲状腺结节 (TN) 的发展.
- 了解这些轨迹对于识别TN的风险因素和预防策略至关重要.
- 之前的研究还没有充分探索纵向BMI变化对TN患病率的影响.
研究的目的:
- 在中国医院队列中识别不同的身体质量指数 (BMI) 轨迹.
- 调查这些水平独立的BMI轨迹与甲状腺结节 (TN) 的患病率之间的关联.
- 确定干预的关键年龄窗口,以减少TN风险.
主要方法:
- 一项对1967名来自中国医院的参与者进行的纵向研究.
- 隐性类增长混合模型 (LCGMM) 用于识别四个不同的BMI轨迹组.
- 分析了2017-2019年的BMI数据 (没有TN) 和2020-2021年的TN发生率,并对共变量进行了调整.
主要成果:
- 在27-50岁年龄组中,BMI水平和TN风险之间发现了显著的关联 (ORs:1.077-1.189).
- 在21-47岁的年龄组中,BMI斜率 (生长率) 和TN风险之间观察到显著的关联 (ORs:1.270-2.490).
- 独立于水平的BMI轨迹显著影响了整个生命周期的TN流行率.
结论:
- 纵向的BMI轨迹是甲状腺结节患病率的重要预测指标.
- 在成年早期 (27-47岁) 控制BMI增长率是TN预防的关键窗口.
- 这些发现强调了终身BMI管理对甲状腺健康的重要性.
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