高系统炎症反应指数 (SIRI) 水平作为治疗性手术后结直肠癌患者的预后因素:单中心回顾性分析
Tamuro Hayama1, Hiroki Ochiai2, Tsuyoshi Ozawa3
1Department of Surgery, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-Ku, Tokyo, 173-8605, Japan. tamuro@med.teikyo-u.ac.jp.
Scientific reports
|January 6, 2025
概括
高系统炎症反应指数 (SIRI) 与结直肠癌 (CRC) 患者的生存率较差有关. 这种炎症标志物独立地预测了更糟糕的无复发和整体存活率,突出了其预后价值.
科学领域:
- 在瘤学瘤学.
- 炎症生物标志物 炎症生物标志物
背景情况:
- 通过系统性炎症反应指数 (SIRI) 评估的系统性炎症与各种癌症的生存率降低有关.
- 以前的研究探讨了手术前SIRI在结直肠癌 (CRC) 复发中的作用.
研究的目的:
- 调查手术前SIRI水平与无复发存活率 (RFS) 和CRC患者的整体存活率 (OS) 之间的联系.
主要方法:
- 对406名患有I-III期CRC的患者进行了回顾性分析,这些患者接受了治疗性手术.
- 患者被分为低SIRI (≤1700) 和高SIRI (>1700) 的两组.
- 使用多变量和卡普兰-梅尔分析.
主要成果:
- 高度的手术前SIRI是5年RFS (p=0.045) 和OS (p=0.048) 的独立风险因素.
- 高SIRI组的5年RFS (p=0.0001) 和OS (p=0.017) 与低SIRI组相比显著较差.
结论:
- 术前SIRI升高显著与结直肠癌患者的预后较差有关.
- 对于接受治疗性手术的CRC患者来说,SIRI是一种有价值的预后指标.
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