对服用免疫检查点抑制剂的肺癌患者同时服用药物的效果进行审查
Han Deng1, Junxiang Zhou1, Zhixi Liu1
1Department of Pharmacy, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, No. 55, Section 4, South Renmin Road, Chengdu, Sichuan, China.
Medical oncology (Northwood, London, England)
|January 6, 2025
概括
同时服用的药物可能会影响肺癌患者的免疫检查点抑制剂 (ICI) 疗效. 一些药物会降低疗效,而其他药物,如阿司匹林,会增强疗效,因此需要个性化治疗策略.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 免疫治疗是一种免疫疗法.
背景情况:
- 免疫检查点抑制剂 (ICI) 对晚期肺癌患者提供了显著的益处.
- 患者通常需要同时服用用于并发症或治疗副作用的药物.
- 了解药物相互作用对于优化ICI治疗结果至关重要.
研究的目的:
- 审查同时服用药物对接受ICI治疗的肺癌患者预后的影响.
- 确定可能影响ICI疗效和患者生存的特定药物类别.
主要方法:
- 对检查肺癌中ICI与药物相互作用的研究的文献综述.
- 对各种同时服用药物的治疗结果所报告的影响的分析.
主要成果:
- 抗生素,质子抑制剂 (PPI),皮质类固醇和阿片类止痛药可能会降低ICI的疗效.
- 阿司匹林和向骨的药物显示出提高ICI疗效和生存率的潜力.
- 甲胺,RASI,NSAIDs (不包括阿司匹林) 和他类药物的作用仍然存在争议.
结论:
- 同时服用的药物显著影响ICI在肺癌中的有效性.
- 某些药物类别需要谨慎使用,而另一些可能是有益的.
- 未来的研究应该专注于个性化药物治疗策略,以优化ICI治疗.
相关概念视频
Tumor Immunotherapy
472
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
472
Drugs Used in Lower Respiratory Disorders: Overview
349
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
349
Cancer Therapies
7.5K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.5K
Combination Therapies and Personalized Medicine
4.8K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.8K
Antiasthma Drugs: Leukotriene Modifiers
241
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Leukotriene modifiers work through two distinct mechanisms:
241


