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Updated: Jun 3, 2025

Co-immunoprecipitation Assay for Studying Functional Interactions Between Receptors and Enzymes
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Co-immunoprecipitation Assay for Studying Functional Interactions Between Receptors and Enzymes

Published on: September 28, 2018

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对aPKC-Par6及其多位极性基质Lgl的捕获,相互抑制和释放机制

Christopher P Earl1, Mathias Cobbaut2,3, André Barros-Carvalho4,5

  • 1Signalling and Structural Biology Laboratory, Francis Crick Institute, London, UK.

Nature structural & molecular biology
|January 6, 2025
PubMed
概括

一个新的结构揭示了非典型的蛋白激酶C (aPKC) 和分区缺陷蛋白6 (Par6) 如何与致命的 (2) 巨型幼虫 (Lgl) 蛋白相互作用. 这种相互作用通过形成抑制酸化的稳定复合体来调节细胞极性.

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