长期服用口服涅马特里尔维尔/里托纳维尔对已确定的长期COVID的影响:一个病例系列
Alison K Cohen1, Toni Wall Jaudon2, Eric M Schurman3
1Department of Epidemiology & Biostatistics and Philip R. Lee Institute for Health Policy Studies, School of Medicine, University of California San Francisco and Patient-Led Research Collaborative, San Francisco, CA, USA. alison.cohen@ucsf.edu.
Communications medicine
|January 6, 2025
概括
延长的帕克斯洛维德 (尼马特里尔维尔/里托纳维尔) 疗程对长期COVID症状有多种益处. 一些患者经历了症状减轻,而另一些患者没有看到任何效果或副作用,表明需要进一步研究.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 之前的研究表明,Paxlovid (nirmatrelvir/ritonavir) 的短疗程可能会使长期COVID患者受益.
- 没有以前的病例系列探索了长期COVID的延长尼尔马特雷尔维尔/里托纳维尔治疗持续时间.
研究的目的:
- 为了研究长期COVID的尼尔马特里尔维尔/里托纳维尔延长疗程的疗效和患者经验.
- 探索患有和没有急性SARS-CoV-2再感染的个体的治疗结果.
主要方法:
- 记录了13名长期COVID患者的病例系列.
- 参与者接受了长期的尼马特里尔维尔/里托纳维尔治疗 (7.5-30天),无论是在急性SARS-CoV-2感染期间还是在外.
- 症状和健康经历在治疗前,治疗期间和治疗后都是自我报告的.
主要成果:
- 在急性感染之外的一些个人经历了有意义的,虽然不总是持久的,症状减少.
- 其他参与者报告说,症状没有改善,或由于胃痛等副作用而停止治疗.
- 在急性再感染期间接受治疗的两名参与者最终恢复到他们感染前的基线.
结论:
- 延长的尼尔马特里尔维尔/里托纳维尔疗程显示可能有利于一些长期COVID患者.
- 结果各不相同,有些人没有体验到好处.
- 需要进一步的研究来确定最佳的治疗持续时间,并确定从长期COVID中使用涅马特里尔维尔/里托纳维尔最受益的患者亚组.
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