相关实验视频

Updated: Jun 3, 2025

Fractionation for Resolution of Soluble and Insoluble Huntingtin Species
07:08

Fractionation for Resolution of Soluble and Insoluble Huntingtin Species

Published on: February 27, 2018

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亨廷顿病的异常拼接伴随着中断的TDP-43活动和改变的m6ARNA修饰

Thai B Nguyen1, Ricardo Miramontes2, Carlos Chillon-Marinas3

  • 1Department of Neurobiology & Behavior, University of California, Irvine, Irvine, CA, USA.

Nature neuroscience
|January 6, 2025
PubMed
概括

亨廷顿病 (HD) 涉及由于CAG重复的改变基因表达. 这项研究揭示了TDP-43和METTL3通过影响RNA处理和m6A修饰来调节HD中的外因子跳转.

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Detection of Alternative Splicing During Epithelial-Mesenchymal Transition

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Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae07:14

Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae

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相关概念视频

Alternative RNA Splicing02:18

Alternative RNA Splicing

Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
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RNA Splicing

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RNA Editing

RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
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Chromatin Structure Regulates pre-mRNA Processing

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The chromatin structure, especially...
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Nonsense-mediated mRNA Decay

The Upf proteins that carry out nonsense-mediated decay (NMD) are found in all eukaryotic organisms, including humans. Each protein has an individual role, but they need to work in collaboration. Upf1 is an ATP-dependent RNA helicase that unwinds the RNA helix. Because Upf1 can unwind any RNA, Upf2 and Upf3 are required to help Upf1 discriminate between nonsense and normal mRNAs.
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Nuclear Export of mRNA

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