农村和种族/种族与儿科癌症早期死亡率之间的关联:基于人口的队列研究,使用2000年至2021年的SEER数据
Kiersten Preuss1, Emma Hymel2, Melissa Acquazzino3
1Department of Epidemiology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Pediatric blood & cancer
|January 6, 2025
概括
种族和民族少数群体和农村地区的儿童面临着更高的儿童癌症早期死亡风险. 解决这些差异对于改善脆弱儿科癌症人群的生存率至关重要.
科学领域:
- 儿科瘤学 儿科瘤学
- 健康差距 研究 研究 研究 研究
- 流行病学 流行病学
背景情况:
- 尽管儿童癌症死亡率下降,但每年仍有超过1000人死亡.
- 现有的关于生存差异的研究往往忽视了早期死亡率 (诊断后12个月内死亡).
- 这项研究专门研究了种族/种族和农村地区对儿童早期癌症死亡率的影响.
研究的目的:
- 分析儿童癌症患者的种族/种族,农村和早期死亡率之间的关联.
- 确定导致诊断后第一年死亡风险增加的特定人口和地理因素.
主要方法:
- 在138,648名儿科癌症患者的队列中利用了SEER研究加上有限的现场数据 (2000-2021年).
- 采用Cox比例危险回归模型来计算危险比率和95%置信区间 (CI).
- 研究了种族/种族,农村和早期死亡结果之间的关联.
主要成果:
- 种族/族裔和农村都与早期死亡率有显著的关联.
- 与非西班牙裔白人儿童相比,非西班牙裔黑人儿童早期死亡的可能性高出70%.
- 不与城市中心相邻的农村县的儿童癌症患者面临着最高的早期死亡风险 (27%的风险增加).
结论:
- 研究结果强调了儿童癌症患者早期死亡率的显著差异.
- 迫切需要解决影响种族/少数民族和农村儿童癌症人口的系统不平等问题.
- 干预措施应侧重于减少这些弱势群体的早期死亡率.
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