伊萨武可纳在粘膜菌的使用:一个系统性审查
Shobha Sanjeewani Gunathilaka1, Reshani Kaumada Keragala2, Kasun Madhumal Gunathilaka3
1Department of Microbiology Faculty of Medicine and Allied Sciences, Rajarata University of Sri Lanka, Saliyapura Sri Lanka, 50008, Sri Lanka.
BMC infectious diseases
|January 6, 2025
概括
伊萨夫可纳在治疗粘膜性肌肉病方面表现有前途,特别是在组合疗法中. 这种抗真菌药物,通常与脂质体安波特素B (LAmB) 一起使用,表现出良好的恢复率,并很少出现不良事件.
科学领域:
- 菌类学 菌类学是指菌类学.
- 传染性疾病 传染性疾病
- 临床药房 临床药房
背景情况:
- 粘菌菌是一种严重的机会性真菌感染,治疗选择有限.
- 脂质体安二乙 (LAmB) 是建议的粘膜菌的第一线治疗方法.
- 伊萨夫可纳是一种潜在的替代或辅助疗法.
研究的目的:
- 系统地审查伊萨武可纳在粘膜病治疗中的疗效和安全性.
- 分析现有证据对isavuconazole,单独或与LAmB结合.
- 从病例报告,系列和临床试验中整合数据.
主要方法:
- 在PubMed,Science Direct,Cochrane Library和其他数据库中进行全面的文献搜索.
- 包括英语文章的人类粘膜菌病,没有时间限制.
- 从31篇选定的文章中提取了有关患者人口统计,治疗细节,结果和不良事件的数据.
主要成果:
- 该审查包括135名成年人和14名儿童接受伊萨武可纳治疗.
- 在不同的抗真菌疗法中,死亡率各不相同,单独治疗伊萨武可纳的死亡率为24.6%.
- 研究的异质性阻止了治疗策略的直接比较.
结论:
- 在急性阶段与伊萨武科纳的联合治疗,随后是口服单一治疗,显示出有希望的康复率.
- 静脉注射LAmB或其他三醇是有效的.
- 伊萨夫可纳与不经常报告的不良事件有关.
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