压力高血糖比率对2型糖尿病的附加效应:基于人口的队列研究
Cancan Cui1, Jiayin Song1, Lingyu Zhang2
1Department of Radiology, China-Japan Union Hospital of Jilin University, Jilin University, Changchun, China.
Cardiovascular diabetology
|January 6, 2025
概括
压力高血糖比率 (SHR) 与患2型糖尿病 (T2D) 的风险更高有关. 这一发现表明,SHR可以帮助预测T2D风险,超出葡萄糖和HbA1c等传统标记.
科学领域:
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
- 流行病学 流行病学
背景情况:
- 压力高血糖比率 (SHR) 是急性高血糖症的新兴标志物.
- 它在2型糖尿病 (T2D) 发展中的作用尚未得到充分证实.
- 不良的临床结果通常与急性高血糖症有关.
研究的目的:
- 调查SHR与T2D发病率之间的关联.
- 为了确定SHR是否可以独立于其他因素来预测T2D风险.
- 评估SHR在T2D风险分层中的有用性.
主要方法:
- 来自中国健康与退休长度研究 (CHARLS) 的45岁以上8978名参与者的队列研究.
- 参与者在基线时没有糖尿病,随访时间为2020年12月31日.
- 使用了Cox比例危险回归和细灰色竞争风险模型,调整了禁食葡萄糖和HbA1c.
主要成果:
- 在7.8年的时间里,1084名参与者患上了T2D.
- 最高的SHR四分位数显示T2D发病风险显著增加 (HR1.48,P<0.001).
- 在添加到葡萄糖和HbA1c模型时,SHR改善了T2D预测AUC (P = 0.013).
结论:
- SHR与事件T2D独立相关.
- SHR可以作为T2D风险分层和预测的宝贵工具.
- SHR提供了超越传统葡萄糖和HbA1c测量的预测价值.
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