希腊克里特岛下呼吸道病原体的流行率和抗菌素耐药性趋势,2017-2022年
Sofia Maraki1, Viktoria Eirini Mavromanolaki2, Anna Kasimati3
1Department of Clinical Microbiology and Microbial Pathogenesis, University Hospital of Heraklion, Crete, Greece. sofiamaraki@yahoo.gr.
Infection & chemotherapy
|January 6, 2025
概括
下呼吸道感染 (LRTI) 中抗菌素耐药性是一个日益令人担忧的问题. 宝曼尼菌 (Acinetobacter baumannii) 的流行率和耐药性增加,需要更新监测以指导治疗.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 下呼吸道感染 (LRTI) 是全球严重的健康负担,导致大量的发病率和死亡率.
- 由于致病原体中抗菌素耐药性 (AMR) 的上升,LRTIs的管理越来越受到挑战.
- 这项研究解决了了解呼吸道感染局部AMR趋势的关键需求.
研究的目的:
- 研究从LRTIs中分离出来的细菌病原体的流行率和时间趋势.
- 为了确定这些关键的呼吸道病原体的抗微生物耐药性模式.
- 为在经验性LRTI治疗中提供数据以提供知情的临床决策.
主要方法:
- 从LRTIs住院患者的呼吸道样本 (唾液,支气管洗) 的回顾性分析.
- 使用矩阵辅助激光吸附离子化-飞行质谱的时间 (MALDI-TOF MS) 来识别细菌.
- 使用Vitek 2系统进行的抗微生物敏感性测试.
主要成果:
- 最常见的分离物是Acinetobacter baumannii (23.1%),在2017-2022年期间出现了显著的增长趋势.
- 对A. baumannii (91.0%) 和Klebsiella pneumoniae (46.2%的卡巴胺耐药性) 观察到高的多药耐药率.
- Pseudomonas aeruginosa对胆固醇素的耐药性较低 (1.4%),而金黄色葡萄球菌对甲基西林的耐药性为37.2%.
结论:
- 对当地的微生物流行病学和AMR模式的持续监测至关重要.
- 监测耐药性趋势对于指导LRTIs有效的实证治疗至关重要.
- 研究结果强调,迫切需要制定策略来应对呼吸道病原体中抗菌素耐药性增加的趋势.
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