老年人的抑郁症状与与压力相关的标记物,功能连接和大脑体积的变化有关
Edelweiss Touron1, Robin de Flores1, Laurent Coulbault1,2
1Normandie Univ, UNICAEN, INSERM, U1237, PhIND "Physiopathology and Imaging of Neurological Disorders", NeuroPresage Team, Institut Blood and Brain @ Caen-Normandie, GIP Cyceron, Bd Henri Becquerel, BP 5229, Caen, 14074, France.
Alzheimer's research & therapy
|January 6, 2025
概括
老年人的亚临床抑郁症状与上腺素水平的升高和海马体灰质体积的减少有关,海马体是易受阿尔茨海默病 (AD) 影响的大脑区域. 早期发现和治疗可能会降低AD风险.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 精神病学是一个精神病学.
背景情况:
- 亚临床抑郁症状是阿尔茨海默病 (AD) 的危险因素.
- 压力系统功能障碍,特别是涉及海马体,可能会调解这种联系.
- 海马对阿尔茨海默病理非常敏感.
研究的目的:
- 为了研究血液压力标志物和老年人的大脑变化之间的关系,有或没有亚临床抑郁症状.
- 探索下丘脑,海马和相关子领域的变化.
- 为了检查静止状态的功能连接 (rs-FC) 和灰色物质 (GM) 体积.
主要方法:
- 从Age-Well试验的基线数据的横截面分析.
- 包括具有 (DepS) 或没有 (NoDepS) 亚临床抑郁症状的认知正常的老年人.
- 测量血皮质醇,上腺素,上腺素,rs-FC和关键大脑区域的GM体积.
主要成果:
- 患有亚临床抑郁症状 (DepS) 的参与者表现出较高的血上腺素水平.
- 升高的上腺素与海马子 (CA1,Subiculum) 和下丘脑之间的rs-FC增加相关.
- 在海马体CA1和DG/CA2-3-4亚场中,DepS组显示GM体积减少.
结论:
- 亚临床抑郁症状与交感 - 上腺髓轴活动增加和海马灰质体积减少有关.
- 这些神经生物学变化,特别是在易患AD的CA1子场中,可能会导致阿尔茨海默病风险增加.
- 在老年人中查和治疗亚临床抑郁症可能会减轻阿尔茨海默病的风险.
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