间歇性禁食在改善代谢障碍患者肝功能方面的有效性:系统性审查和元分析
Mousa Khalafi1, Sara K Rosenkranz2, Faeghe Ghasemi3
1Department of Physical Education and Sport Sciences, Faculty of Humanities, University of Kashan, Kashan, Iran.
Nutrition & metabolism
|January 6, 2025
概括
间歇性禁食 (IF) 通过减少肝脏脂肪,脂肪和肝脏酶,如ALT和AST,改善成年人代谢障碍的肝功能. 这些好处在各种IF方法和参与者人口统计学中得到观察.
科学领域:
- 代谢障碍 代谢障碍 代谢障碍
- 营养科学 营养科学
- 肝病学 肝病学是一种肝病学.
背景情况:
- 间歇性禁食 (IF) 显示出减肥和心脏代谢健康的前景.
- 关于IF在代谢障碍中对肝功能的影响的证据有限.
- 这项研究研究了IF对成年人代谢障碍肝功能指标的影响.
研究的目的:
- 系统地审查和分析间歇性禁食 (IF) 对代谢障碍的成年人肝功能的影响.
- 评估IF对肝脏脂肪,脂肪,纤维化和肝酶 (ALT,AST) 的影响.
主要方法:
- 对21项涉及1226名参与者的研究进行了系统性审查和元分析.
- 搜索了PubMed,科学网络和Scopus数据库.
- 使用随机效应模型分析了包括肝脂肪,脂肪,纤维化,ALT和AST在内的结果.
主要成果:
- IF显著减少了肝脏脂肪 (SMD: -1.22),肝脏肥胖症 (SMD: -0.73),ALT (SMD: -0.44) 和AST (SMD: -0.30).
- 没有发现对肝纤维化的显著影响 (SMD: -0.28).
- 在不同投资模式,持续时间和参与者特征中,收益是一致的.
结论:
- 间歇性禁食是一种有效的饮食疗法,可以改善代谢障碍的成年人肝功能.
- 肝功能标志物的改善在很大程度上独立于IF治疗方案和参与因素.
- 由于研究的局限性,建议进行进一步的随机试验.
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