重复静脉注射esketamine对情感偏差的影响
Christine Reif-Leonhard1, Shannon N Millard2, Dorsa Ferdowssian1
1Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt - Goethe University Frankfurt, Frankfurt am Main, Germany.
概括
在治疗耐药性抑郁症的患者中,Esketamine治疗改善了情绪识别和认知功能. 这些改善,特别是处理悲伤的改善,在重复注射后得到巩固,这表明在长期抗抑郁药反应中发挥了作用.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 传统的抗抑郁药具有记录良好的神经心理效应.
- 对快速起作用的抗抑郁药物的研究,如胺,需要进一步调查它们对认知和情绪的影响.
研究的目的:
- 检查埃斯基他胺对情绪处理和认知功能的急性和次慢性影响.
- 为了研究与治疗耐药抑郁症 (TRD) 患者的esketamine治疗相关的神经心理变化.
主要方法:
- 十八名TRD患者接受了反复的静脉注射esketamine输液.
- 每天的情绪状态被报告,情绪识别 (面部表情识别任务) 和认知功能 (数字符号替代任务) 在输注前后被评估.
主要成果:
- 66.7%的参与者在至少五次输液后显著改善.
- 对大多数情绪的情绪识别有所改善,对悲伤的准确性降低,但减少了将其他情绪错误分类为悲伤的偏见.
- 观察到悲伤和易怒的显著减少,以及认知功能的改善.
结论:
- 乙胺治疗可以通过改变情绪处理和认知来改善TRD.
- 急性情绪提升效应与持续时间较长的抗抑郁药物反应不同,这些抗抑郁药物在重复服用时会得到巩固.
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