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肠道神经传递的可塑性在昼夜周期和养状态下变化

Anita J L Leembruggen¹, Gunes S Yildiz¹, Justin P Hardee^1,2

¹Department of Anatomy and Physiology, The University of Melbourne, Melbourne, Victoria, Australia.

American journal of physiology. Gastrointestinal and liver physiology

|January 7, 2025

概括

肠道神经系统肠道神经系统

科学领域:

神经科学是一个神经科学.
胃肠病学胃肠病学
时间生物学时间生物学

背景情况:

昼夜周期影响生理功能,包括胃肠道活动.
肠道神经系统 (ENS) 协调肠道功能,但其昼夜调节尚不清楚.

研究的目的:

调查昼夜周期和禁食如何影响肠道神经系统活动.
为了检查24小时内和禁食后肠道神经传递的变化.

主要方法:

在小鼠中活成像以评估肠道神经元活动.
在昼夜周期和急性禁食后对肠道神经递质的分析.

主要成果:

在小鼠的黑暗阶段 (活跃/食) 中,肠道神经元活动增加.
一个急性快速转移峰值肠道神经元活动到光阶段.
神经元活动的变化与神经递质受体基因表达没有相关性.

结论:

肠道神经系统的活动是由昼夜周期和食模式动态调节的.
禁食急剧改变了肠道神经元活动的时间,这表明昼夜肠道调节中的可塑性.

关键词:

的成像成像技术可以帮助我们.昼夜循环周期的循环周期.时钟基因的时间基因肠道神经系统肠道神经系统

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