相关实验视频

Updated: Jun 3, 2025

Analysis of β-Amyloid-induced Abnormalities on Fibrin Clot Structure by Spectroscopy and Scanning Electron Microscopy
06:27

Analysis of β-Amyloid-induced Abnormalities on Fibrin Clot Structure by Spectroscopy and Scanning Electron Microscopy

Published on: November 30, 2018

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人类大脑光滑肌细胞上的Aβ40纤维组合损害了细胞活力

Brandon Irizarry1, Judianne Davis2, Jitika Rajpoot1

  • 1Center for Structural Biology, Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York 11794-5215, United States.

Biochemistry
|January 7, 2025
PubMed
概括

大脑粉样蛋白血管病变 (CAA) 涉及粉样蛋白-β (Aβ) 在脑血管中的积累. 这项研究表明,纤维状Aβ种子在光滑肌肉细胞上促进新的粉样蛋白形成,导致细胞死亡和疾病的进展.

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In Vitro Assays to Assess Blood-brain Barrier Mesh-like Vessel Formation and Disruption10:36

In Vitro Assays to Assess Blood-brain Barrier Mesh-like Vessel Formation and Disruption

Published on: June 20, 2017

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Visualizing Axonal Growth Cone Collapse and Early Amyloid β Effects in Cultured Mouse Neurons06:23

Visualizing Axonal Growth Cone Collapse and Early Amyloid β Effects in Cultured Mouse Neurons

Published on: October 30, 2018

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相关概念视频

Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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