用硫氧化物治疗降低了康复期COVID-19患者内皮功能障碍的生物标志物
Alejandro J Gonzalez-Ochoa1,2, Gyozo Szolnoky3, Ana G Hernandez-Ibarra4
1Vascular Surgery Department, Centro Médico del Noroeste, San Luis Rio Colorado, Sonora, México.
概括
硫氧化物在康复的COVID-19患者中降低了关键的内皮功能障碍生物标志物,如血栓模块素和·威勒布兰德因子. 这表明硫氧化物可能会防止长期COVID相关的血管问题.
科学领域:
- 心血管医学 心血管医学
- 药理学 药理学是指药理学的学科.
- 传染性疾病 传染性疾病
背景情况:
- 持续性内皮功能障碍生物标志物COVID-19后与长期心血管风险有关,包括长期COVID综合征.
- 硫氧化物具有血管内皮的亲和力和保护性.
- 在COVID-19康复过程中,评估硫氧化物对内皮功能障碍生物标志物的影响至关重要.
研究的目的:
- 评估硫氧化物在缓解内皮功能障碍标志物的有效性,在COVID-19康复阶段.
- 调查硫氧化物在减少COVID-19后与长期心血管并发症相关的生物标志物的潜力.
主要方法:
- 一个双盲,随机,安慰剂对照试验进行了8周.
- 在COVID-19早期康复阶段的成年患者接受硫氧化物 (250LRU每天两次) 或安慰剂.
- 血清生物标志物水平,以血栓模块素 (TM) 为主要终点,使用重复测量和后期测试进行了分析.
主要成果:
- 与安慰剂相比,硫氧化物组在第8周显示出血栓模块素 (TM),·威尔布兰德因子 (vWF) 和介质素-6 (IL-6) 的平均水平明显较低.
- 硫氧化物还导致了D-二聚体和C-反应蛋白 (CRP) 水平的降低.
- 对于P-选择素,纤维素原,VCAM-1或ICAM-1没有发现显著差异.
结论:
- 在康复的COVID-19患者中,使用硫氧化物治疗八周后,降低了TM,vWF,D-二次体,CRP和IL-6的血清水平.
- 这些发现表明硫氧化物对COVID-19后的血栓炎症和内皮损伤有潜在的保护作用.
- 硫氧化物可能提供一种治疗策略,用于管理COVID-19的长期心血管后果.
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