在缺血性中风后的糖尿病前期和二型糖尿病
Kurt Moelgg1,2, Anel Karisik1,2, Lukas Scherer1,2
1Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
European stroke journal
|January 7, 2025
概括
在中风幸存者中,糖尿病的进展很常见. 许多患者可能有资格参加新的糖尿病药物试验,如GLP-1-RA和SGLT-2抑制剂,为二次预防提供潜力.
科学领域:
- 神经学 神经学
- 内分泌学 在内分泌学.
- 心血管医学 心血管医学
背景情况:
- 在中风后的患者中,糖尿病状况的进展尚未得到充分研究.
- 新型二型糖尿病 (DM II) 治疗方法,包括葡萄糖样1受体激动剂 (GLP-1-RA) 和-葡萄糖共运输体-2 (SGLT-2) 抑制剂,在中风后的环境中缺乏研究.
研究的目的:
- 在一年内评估缺血性中风患者的血糖状况变化.
- 为了确定与血糖状况进展相关的因素.
- 审查中风患者在新型糖尿病药物试验中的资格.
主要方法:
- 来自STROKE-CARD注册表的884名缺血性中风患者的前性评估.
- 在基线和1年随访时评估血糖状况 (正常血糖,糖尿病前期,DM II).
- 多变量逻辑回归以确定进展因素和正在进行的临床试验的审查.
主要成果:
- 在基线时,44.6%的患者患有正常血糖,33.9%的患者患有糖尿病前期,21.5%的患者患有II型糖尿病.
- 1年后,正常血糖降低,而糖尿病前期和DM II增加.
- 静止剂治疗是病情进展的唯一显著风险因素;23.4%的患者符合塞马格卢提德试验的标准.
结论:
- 糖尿病前期和II型糖尿病是普遍存在的,并且在缺血性中风幸存者中进展.
- 很大一部分中风幸存者可能有资格参加研究GLP-1-RA和SGLT-2抑制剂的试验.
- 需要进行临床试验来评估这些新型糖尿病治疗方法对中风患者群体的治疗.
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