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发展黑色素瘤的吸烟者的结果:系统性审查和元分析
Erica B Friedman1, Gabrielle J Williams2,3, Serigne N Lo2,3
1Department of Surgery, New York University Langone Health, New York, NY, USA.
EClinicalMedicine
|January 7, 2025
概括
与从未吸烟者相比,目前吸烟者面临的黑色素瘤死亡风险高出33%. 前吸烟者有类似的生存率. 吸烟也增加了哨戒节阳性和手术并发症的风险.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 黑色素瘤发病率在吸烟者中较低,但生存结果的理解较少.
- 吸烟者的黑色素瘤复发和死亡风险增加需要进一步调查.
- 根据吸烟状况,黑色素瘤患者的生存差异的大小没有得到充分记录.
研究的目的:
- 系统地审查和分析吸烟者与从不吸烟者的黑色素瘤生存结果.
- 量化吸烟黑色素瘤患者的生存差异的大小.
- 为了比较当前吸烟者,前吸烟者和从未吸烟者之间的黑色素瘤复发和死亡风险.
主要方法:
- 在Medline,Embase和Cochrane CENTRAL数据库中进行系统的文献搜索.
- 包括研究报告黑色素瘤的结果 (疾病严重程度,死亡风险,治疗效果) 在吸烟者和不吸烟者.
- 使用纽卡斯尔-太华工具和在PROSPERO注册协议进行偏差风险评估.
主要成果:
- 分析了46项研究,包括164,166名患者;70,766人是吸烟者.
- 与从未吸烟者相比,目前吸烟者患黑色素瘤死亡的风险高出33% (HR 1.33).
- 前吸烟者与从未吸烟者 (HR 1.04) 的黑色素瘤死亡率相似.
- 目前的吸烟者具有更高的哨兵节点阳性和节点手术并发症的风险.
结论:
- 目前的吸烟者有明显增加死于黑色素瘤的风险.
- 与从未吸烟者相比,前吸烟者似乎没有较高的黑色素瘤死亡风险.
- 吸烟与黑色素瘤患者中哨戒节阳性和手术并发症的风险增加有关.
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