经期的年龄和冠状动脉疾病风险:与不同来源变化的不同关联
Ambreen Sonawalla1,2, Daniel I Chasman2,3, Yee-Ming Chan1,2
1Division of Endocrinology, Department of Pediatrics, Boston Children's Hospital.
medRxiv : the preprint server for health sciences
|January 7, 2025
概括
晚期初潮 (AAM) 的晚年并不直接增加冠状动脉疾病 (CAD) 的风险. 相反,其他因素影响AAM和CAD风险,表明AAM不是CAD的直接原因.
科学领域:
- 心血管疾病的研究研究.
- 生殖健康 生殖健康
- 遗传流行病学遗传流行病学
背景情况:
- 初潮时的早期和晚年 (AAM) 都与女性冠状动脉疾病 (CAD) 风险更高有关.
- 影响CAD风险的AAM变化的具体来源尚不清楚.
研究的目的:
- 调查AAM和CAD之间的关系是否根据AAM变化的来源有所不同.
- 为了区分基因预测的AAM和受其他因素影响的AAM的影响.
主要方法:
- 利用英国生物库 (201,037名女性) 和女性基因组健康研究 (23,268名女性) 的数据.
- 计算了AAM的多基因分数 (PGS),并得出了基因预测的AAM和PGS调整的AAM.
- 使用后勤回归和线性线条来分析与CAD和风险因素的关联.
主要成果:
- 基因预测的AAM显示与CAD和相关风险因素有线关联.
- 经PGS调整的AAM与CAD,血红蛋白A1c,甘油三,HDL-C和腰部和部比率呈现出U形关系.
- 验证研究证实了这些发现.
结论:
- 晚期AAM并不是增加CAD风险的直接原因.
- 影响AAM的非遗传因素似乎也导致CAD风险.
- 低血糖,低脂血症和中心脂肪可能会调解后期AAM和CAD风险之间的关联.
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