戴族和汉族人口之间的口腔微生物群与2型糖尿病相关的差异
Lingtong Tang1,2, Keke Ding3, Mengci Li3
1Department of Clinical Laboratory, The People's Hospital of Gao County, Yibin, Sichuan, China.
年龄和种族在2型糖尿病 (T2DM) 中显著影响口腔微生物群. 与汉族人群相比,患有T2DM的戴族人群表现出明显的微生物转移,年龄是关键的差异化因素.
科学领域:
- 微生物组研究的研究.
- 人类遗传学 人类遗传学
- 代谢性疾病研究研究.
背景情况:
- 2型糖尿病 (T2DM) 的发展受到影响,影响微生物群的地理,种族,性别和年龄相关因素.
- 口腔微生物群在T2DM中的作用是公认的,但像戴族和汉族人群这样的不同种族群体内的特定关联仍未得到充分探索.
研究的目的:
- 为了比较T2DM和没有T2DM的Dai和Han种群之间的口腔微生物群组成.
- 确定这些族群中与T2DM相关的关键微生物物种和网络差异.
主要方法:
- 在健康儿童,健康成年人和患有T2DM的成年人中招募了28名汉族和34名戴族参与者.
- 采集血液用于生物化学分析和唾液用于16SrRNA测序,以分析口腔微生物群.
主要成果:
- 在区分戴族和汉族人口之间的口腔微生物群方面,年龄比糖尿病更为重要.
- 与汉族人群相比,患有T2DM的戴族人群表现出 *Alistipes putredinis *, *Lactobacillus spp *, *Faecalibacterium prausnitzii *和 *Akkermansia muciniphila * 的水平增加.
- 确定了不同的基石属:在戴网络中的*Fusibacter*和在汉族人口中更分散的网络.
结论:
- 这项研究提供了第一份对受T2DM影响的戴族和汉族人口口腔微生物群的比较分析.
- 研究结果强调了年龄和种族对T2DM的口腔微生物组成的重大影响.
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