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Updated: Jun 3, 2025

A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information
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路径多基因风险评分 (pPRS) 用于分析基因环境相互作用

W James Gauderman1, Yubo Fu1, Bryan Queme2

  • 1Division of Biostatistics, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.

bioRxiv : the preprint server for biology
|January 7, 2025
PubMed
概括

路径定义的多基因风险评分 (pPRS) 提高了对复杂疾病的基因环境相互作用的检测. 这种方法在特定的遗传途径中确定了NSAID使用和结直肠癌风险之间的显著相互作用.

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