条状体区分,体和矩阵,嵌入在很大程度上不同的静止状态功能网络中
Alishba Sadiq1, Adrian T Funk1, Jeff L Waugh1
1Division of Pediatric Neurology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, United States.
bioRxiv : the preprint server for biology
|January 7, 2025
概括
这项研究绘制了人类状体的体和矩阵区的独特功能性大脑网络. 研究结果显示,这些隔间与不同的大脑网络相连,这对于理解条纹损伤和神经精神疾病至关重要.
科学领域:
- 神经科学是一个神经科学.
- 人类大脑成像技术
- 功能神经解剖学 功能神经解剖学
背景情况:
- 条形体由两部分组成:条形体和矩阵,在运动和情绪功能中发挥着不同的作用.
- 了解人类的特定功能是有限的,但对于神经精神疾病的洞察力至关重要.
- 之前的研究已经提出了假设,但没有直接测试人类大脑网络中分区特定的角色.
研究的目的:
- 绘制人体状体中与体和矩阵部分相关的体内功能网络的地图.
- 研究体样和矩阵样声细胞的独特静止状态功能连接 (rsFC) 模式.
- 为了确定这些条纹区与主要大脑网络 (默认模式,突出,前层双层) 的参与.
主要方法:
- 利用了来自人类结合体项目的674名健康成年人的扩散和功能性MRI数据.
- 通过概率扩散通道学识别了具有体样和矩阵样结构连接的条状声.
- 分析了静止状态功能连接 (rsFC) 使用像隔间的voxels作为种子,评估网络主导地位和三重网络模型参与.
主要成果:
- 在体状和矩阵状种子之间,在rsFC中表现出广泛的,解剖学上精确的差异,表明不同的功能网络.
- 体种子网络显示出ipsilateral主导地位,而矩阵种子网络显示出 contralateral 主导地位.
- 与默认模式网络和前面岛屿密切连接的状声;与前面双相网络节点有更强的连接的矩阵状声.
结论:
- 体和矩阵区占据了人类大脑中高度分离的功能网络.
- 分区选择性条纹性损伤可能会产生明显的运动,认知和行为症状.
- 识别rsFC异常可能会在结构损伤之前出现,为理解神经精神疾病提供了基质.
关键词:
隔间的隔间是指隔间的隔间.扩散通道学 扩散通道学功能性核磁共振成像 (MRI) 功能性核磁共振成像功能连接性的功能连接性这是一个矩阵矩阵.条纹体的条纹体.状体是什么? 状体是什么?结构连接性的结构连接性更多相关视频
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