相关实验视频
Updated: Jun 3, 2025
12:05
Co-staining Blood Vessels and Nerve Fibers in Adipose Tissue
Published on: February 13, 2019
9.2K
在肥胖中血管源信号的综合分析:毛细血管特征和VEGF结合动力学
bioRxiv : the preprint server for biology
|January 7, 2025
概括
肥胖显著改变脂肪组织,减少血管密度和大小. 了解血管内皮生长因子A (VEGF-A) 信号传递对于开发新的肥胖疗法至关重要.
科学领域:
- 生理学 生理学 生理学
- 分子生物学分子生物学
- 系统生物学 系统生物学
背景情况:
- 肥胖是一个全球性的健康危机,超过42%的美国成年人肥胖.
- 脂肪组织的扩张依赖于血管生成,主要通过血管内皮生长因子A (VEGF-A).
- 目前关于肥胖VEGF-A的数据分散,阻碍了治疗的发展.
研究的目的:
- 综合现有的关于肥胖的脂肪血管微环境的文献.
- 为系统生物学对肥胖的建模标准化数据.
- 提供对肥胖引起的脂肪组织变化的整体观点.
主要方法:
- 综合文献分析和数据挖掘.
- 不同数据点的标准化.
- 脂肪组织血管结构与瘤血管结构的比较分析.
主要成果:
- 肥胖会增加脂肪细胞的大小 (78%) 并降低脂肪组织血管密度 (51%).
- 肥胖脂肪组织血管较小 (47-58%),但与瘤血管相比更密集.
- VEGF-A对VEGFR1具有最强的结合,对VEGFR2和NRP1.1有不同的亲和力.
结论:
- 综合发现为肥胖的系统生物学模型提供了参数.
- 提供了有关肥胖的脂肪组织血管变化的新见解.
- 为开发针对肥胖的新型血管生成向疗法奠定了基础.
相关概念视频
01:24Regulation of Angiogenesis and Blood Supply
2.5K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.5K
01:10Mechanism of Angiogenesis
5.2K
Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
5.2K