Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Immunological Memory01:23

Immunological Memory

524
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
524
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

951
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
951
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

66.8K
Overview
66.8K
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

651
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
651
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

742
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
742
Retrovirus Life Cycles01:10

Retrovirus Life Cycles

45.6K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
45.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Temperature and developmental stage govern intestinal susceptibility to human coronavirus 229E.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Antigen Stimulation Reactivates HIV-1 Proviruses Despite Integration in Repressive Chromatin.

bioRxiv : the preprint server for biology·2026
Same author

Microbial metabolites at the front line: Orchestrating gastrointestinal and systemic barrier immunity across the lifespan.

Cell reports·2026
Same author

Early-life mucosal T cells direct intestinal stem cell fate via a coordinated developmental program.

bioRxiv : the preprint server for biology·2026
Same author

Immune development in early life.

Nature immunology·2026
Same author

BACH2 effector-to-memory switch promotes HIV persistence and CAR-T efficacy.

Current opinion in HIV and AIDS·2026
Same journal

A human-specific genetic modifier reconfigures large-scale cortical network dynamics underlying behavioral performance.

bioRxiv : the preprint server for biology·2026
Same journal

<i>Staphylococcus aureus</i> uses a eukaryotic-like uridyltransferase to make UDP-GlcNAc for cell wall synthesis.

bioRxiv : the preprint server for biology·2026
Same journal

Dynamic redistribution of eIF4F controls cap-dependent translation initiation.

bioRxiv : the preprint server for biology·2026
Same journal

When does additional information improve accuracy of RNA secondary structure prediction?

bioRxiv : the preprint server for biology·2026
Same journal

Normative brain-state trajectories reveal deviation from healthy aging in Alzheimer's disease.

bioRxiv : the preprint server for biology·2026
Same journal

Noradrenergic infraslow rhythm during sleep is the critical link between heart-rate dynamics and memory consolidation.

bioRxiv : the preprint server for biology·2026
查看所有相关文章

相关实验视频

Updated: Jun 3, 2025

Application of Long-term cultured Interferon-&#947; Enzyme-linked Immunospot Assay for Assessing Effector and Memory T Cell Responses in Cattle
15:57

Application of Long-term cultured Interferon-γ Enzyme-linked Immunospot Assay for Assessing Effector and Memory T Cell Responses in Cattle

Published on: July 11, 2015

12.2K

BACH2驱动的组织内存程序促进了HIV-1的持续性.

Yulong Wei1, Haocong Katherine Ma1, Michelle E Wong1

  • 1Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06519, USA.

bioRxiv : the preprint server for biology
|January 7, 2025
PubMed
概括
此摘要是机器生成的。

转录抑制剂BACH2通过在肠道中产生长寿记忆T细胞来促进HIV-1的持久性. 向BACH2可能为HIV-1感染提供新的治疗策略.

关键词:
在 BACH2 的基础上.艾滋病毒-1持续性 艾滋病毒-1持续性艾滋病毒-1 储存库T细胞的克隆扩张.组织居民记忆T细胞

更多相关视频

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models
09:54

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models

Published on: December 3, 2019

8.9K
Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice
06:07

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice

Published on: October 6, 2022

2.3K

相关实验视频

Last Updated: Jun 3, 2025

Application of Long-term cultured Interferon-&#947; Enzyme-linked Immunospot Assay for Assessing Effector and Memory T Cell Responses in Cattle
15:57

Application of Long-term cultured Interferon-γ Enzyme-linked Immunospot Assay for Assessing Effector and Memory T Cell Responses in Cattle

Published on: July 11, 2015

12.2K
Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models
09:54

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models

Published on: December 3, 2019

8.9K
Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice
06:07

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice

Published on: October 6, 2022

2.3K

科学领域:

  • 免疫学 免疫学 免疫学
  • 病毒学 病毒学
  • 分子生物学分子生物学

背景情况:

  • 转录抑制剂BACH2影响T细胞分化和记忆形成.
  • 艾滋病毒-1 确立了肠道内特定T细胞子集的持久性.

研究的目的:

  • 研究BACH2在肠道CD4+T细胞内HIV-1持久性中的作用.
  • 确定BACH2作为HIV-1持久性的潜在治疗点.

主要方法:

  • 结合单细胞DOGMA-seq和TREK-seq来分析100,744个肠道T细胞中的染色质可访问性,转录组,表面蛋白质,T细胞受体,HIV-1 DNA和RNA.
  • 比较来自AVIREMICHIV-1+个体和HIV-1捐赠者的细胞.
  • 在体外对肠道CD4+T细胞进行了感染.

主要成果:

  • BACH2将肠道组织的T细胞 (TRM) 塑造为具有减少效应因子功能的长寿命记忆细胞.
  • 感染HIV-1的细胞富含TRM (80.8%),并显示增加了BACH2的可访问性,TRM/生存基因表达和Th17极化.
  • 在体外研究表明,偏好的HIV-1感染和持久性在CCR6+TRMs.

结论:

  • 由BACH2驱动的TRM计划促进了HIV-1在肠道中的持久性.
  • BACH2代表了一种用于控制HIV-1持续性的新疗法标.