通过加密口袋映射加上X射线片段查,加强了与hnrnpa1结合的小分子的识别

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Updated: Jun 24, 2026

Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b
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Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b

Published on: November 11, 2016

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Louise Dunnett1, Sayan Das2, Vincenzo Venditti2

  • 1Diamond Light Source Ltd., Harwell Science and Innovation Campus, Didcot OX11 0QX, UK.

bioRxiv : the preprint server for biology
|January 7, 2025
PubMed
概括

研究人员在hNRNPA1蛋白中发现了神秘的口袋.

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Applications Of NMR In Biology01:25

Applications Of NMR In Biology

Nuclear magnetic resonance (NMR) spectroscopy is a very valuable analytical technique for researchers. It has been used for more than 50 years as an analytical tool. F. Bloch and E. Purcell formulated NMR in 1946 and won the 1952 Nobel Prize in Physics  for their work. Biological macromolecules such as proteins, nucleic acids, lipids, and organic molecules including pharmaceutical compounds, can be studied using this versatile tool that exploits the magnetic properties of certain nuclei.
The...