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Updated: Jun 3, 2025

Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
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APOE4增加了对粉样蛋白的敏感性,加速了情节性记忆衰退.

Casey R Vanderlip1, Craig E L Stark1

  • 1Department of Neurobiology and Behavior, University of California Irvine.

bioRxiv : the preprint server for biology
|January 7, 2025
PubMed
概括

最强的阿尔茨海默病 (AD) 遗传风险因素,阿波利波蛋白E4 (APOE4),加速了情节性记忆衰退. 这种下降与粉样蛋白持续时间有关,并且是剂量依赖的,突出显示了APOE4对记忆的特定影响.

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