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Updated: Jun 3, 2025

Examining BCL-2 Family Function with Large Unilamellar Vesicles
08:35

Examining BCL-2 Family Function with Large Unilamellar Vesicles

Published on: October 5, 2012

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在BAX中,一个封闭的疏水漏斗将长链基结合起来,以增强亲细胞灭绝的功能

Jesse D Gelles1,2,3, Yiyang Chen1,2,3,4, Mark P A Luna-Vargas1,2,3

  • 1Laboratory of Mitochondrial Biology in Human Health and Disease, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, New York 10029, USA.

bioRxiv : the preprint server for biology
|January 7, 2025
PubMed
概括

线粒体与仅BH3的蛋白质合作激活BAX,从而启动细胞亡. 代谢物2-trans-hexadecenal将BAX结合到一个新的"道"区域,增强这种激活并提供治疗潜力.

关键词:
细胞灭亡 (apoptosis) 是一种死亡的过程.巴克斯巴克斯 (BAX) 是一个在BCL-2家族中.细胞死亡 细胞死亡十六分之一年这就是MOMP.α,β-不和基

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