Search research articles

关于 JoVE

概览领导团队博客 JoVE 帮助中心

作者

出版流程编辑委员会范围与政策同行评审常见问题投稿

图书馆员

用户评价订阅访问资源图书馆顾问委员会常见问题

研究

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments 存档

教育

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual 教师资源中心教师网站

使用条款与条件

相关概念视频

Protein Diffusion in the Membrane

Protein Diffusion in the Membrane

Proteins show rotational as well as lateral diffusion across the membrane. The lateral diffusion of proteins was confirmed through the cell fusion experiment where mouse and human cells were fused, resulting in hybrid cells. When the human and mouse cells fused, the specific membrane proteins on human and mouse cells were marked with the red and green-fluorescent markers, respectively. Initially, the red and green fluorescence was located on the respective hemisphere of the cell. As time...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序

Same author

Auto-segmentation of organs-of-interest clinical acceptability & reproducibility framework in head and neck cancer.

Physics and imaging in radiation oncology·2026

Same author

Identifying and targeting abnormal mitochondrial localization associated with psychosis.

bioRxiv : the preprint server for biology·2026

Same author

Making head and neck cancer clinical data Findable-Accessible-Interoperable-Reusable to support multi-institutional collaboration and federated learning.

BJR artificial intelligence·2026

Same author

GloBIAS: strengthening the foundations of bioimage analysis.

Nature methods·2026

Same author

Progress and new challenges in image-based profiling.

Molecular systems biology·2026

Same author

Cell Painting for cytotoxicity and mode-of-action analysis in primary human hepatocytes.

Cell systems·2026

Same journal

Layered social competition coordinates reproductive hierarchy formation in ants.

bioRxiv : the preprint server for biology·2026

Same journal

Combination epigenetic-targeted therapy increases the immunogenicity of poorly immunogenic sarcomas.

bioRxiv : the preprint server for biology·2026

Same journal

Loss of LanC-like proteins delays post-injury regeneration of aging skeletal muscles.

bioRxiv : the preprint server for biology·2026

Same journal

Integrative Transfer Network: Deep Transfer Learning Across Populations and Prediction Targets.

bioRxiv : the preprint server for biology·2026

Same journal

Confidence-supported label-free metabolic imaging with FPhaS phase autofluorescence microscopy.

bioRxiv : the preprint server for biology·2026

Same journal

Sequence-encoded autoinhibition couples mRNA decapping activity to phase separation.

bioRxiv : the preprint server for biology·2026

查看所有相关文章

Search research articles

相关实验视频

Updated: Jun 3, 2025

A Method for Determination and Simulation of Permeability and Diffusion in a 3D Tissue Model in a Membrane Insert System for Multi-well Plates

A Method for Determination and Simulation of Permeability and Diffusion in a 3D Tissue Model in a Membrane Insert System for Multi-well Plates

Published on: February 23, 2018

MorphoDiff:细胞形态绘画与扩散模型

Zeinab Navidi^1,2,3, Jun Ma^2,3, Esteban A Miglietta⁴

¹Department of Computer Science, University of Toronto, Toronto, ON, Canada.

bioRxiv : the preprint server for biology

|January 7, 2025

概括

此摘要是机器生成的。

MorphoDiff是一个新的AI管道,可以预测细胞形态变化的化学或遗传扰乱. 这种工具可以生成高分辨率的细胞图像,通过在 silico 中探索细胞反应来帮助药物发现.

更多相关视频

Image Processing Protocol for the Analysis of the Diffusion and Cluster Size of Membrane Receptors by Fluorescence Microscopy

Image Processing Protocol for the Analysis of the Diffusion and Cluster Size of Membrane Receptors by Fluorescence Microscopy

Published on: April 9, 2019

Planar Gradient Diffusion System to Investigate Chemotaxis in a 3D Collagen Matrix

Planar Gradient Diffusion System to Investigate Chemotaxis in a 3D Collagen Matrix

Published on: June 12, 2015

相关实验视频

Last Updated: Jun 3, 2025

A Method for Determination and Simulation of Permeability and Diffusion in a 3D Tissue Model in a Membrane Insert System for Multi-well Plates

A Method for Determination and Simulation of Permeability and Diffusion in a 3D Tissue Model in a Membrane Insert System for Multi-well Plates

Published on: February 23, 2018

Image Processing Protocol for the Analysis of the Diffusion and Cluster Size of Membrane Receptors by Fluorescence Microscopy

Image Processing Protocol for the Analysis of the Diffusion and Cluster Size of Membrane Receptors by Fluorescence Microscopy

Published on: April 9, 2019

Planar Gradient Diffusion System to Investigate Chemotaxis in a 3D Collagen Matrix

Planar Gradient Diffusion System to Investigate Chemotaxis in a 3D Collagen Matrix

Published on: June 12, 2015

科学领域:

细胞生物学细胞生物学
生物信息学是一种生物信息学.
计算生物学计算生物学

背景情况:

了解细胞对刺激的反应对于生物研究和药物开发至关重要.
基于图像的高含量测试对于研究细胞表型和生物过程具有成本效益.

研究的目的:

介绍MorphoDiff,一种用于预测高分辨率细胞对干扰的形态反应的生成管道.
在化学和遗传干预中提供第一个指导,高分辨率的细胞形态预测框架.

主要方法:

整合扰动嵌入作为指导信号在2D隐性扩散模型.
使用三个开源的细胞绘画数据集进行验证.

主要成果:

MorphoDiff可以生成高准确度的细胞形态图像.
该模型在各种干预措施中产生生物学上有意义的信号.
在化学和遗传乱中证明了泛化.

结论:

莫尔福迪夫 (MorphoDiff) 便于对扰乱景观进行高效的in silico探索.
该框架通过预测细胞反应,支持更有效的药物发现研究.