相关实验视频

Updated: Jun 3, 2025

Analysis of Interactions between Endobiotics and Human Gut Microbiota Using In Vitro Bath Fermentation Systems
00:06

Analysis of Interactions between Endobiotics and Human Gut Microbiota Using In Vitro Bath Fermentation Systems

Published on: August 23, 2019

6.9K

肠道微生物介导药物代谢的计算分析

Sammie Chum, Alberto Naveira Montalvo, Soha Hassoun

    bioRxiv : the preprint server for biology
    |January 7, 2025
    PubMed
    概括

    这项研究引入了一种计算方法,可以预测肠道微生物如何代谢药物,从而改善药物开发. 该方法准确地识别了肠道微生物环境中的潜在药物代谢物.

    更多相关视频

    An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota07:15

    An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

    Published on: July 31, 2019

    9.5K
    Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota06:23

    Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota

    Published on: February 15, 2019

    14.1K

    相关概念视频

    Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

    Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

    Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
    173
    Factors Affecting Drug Biotransformation: Physicochemical and Chemical Properties of Drugs01:21

    Factors Affecting Drug Biotransformation: Physicochemical and Chemical Properties of Drugs

    A drug's physicochemical properties fundamentally influence its metabolism. For instance, a drug's molecular size and shape critically determine its interaction with enzymes and transporters — larger drugs may face difficulty reaching enzyme active sites, altering their metabolic pathways. The pKa of a drug, which establishes its ionization state, can impact its solubility and absorption, thereby influencing metabolism.
    The drug's acidity or basicity is essential in...
    178
    Factors Affecting Drug Biotransformation: Biological01:19

    Factors Affecting Drug Biotransformation: Biological

    Biological factors significantly impact drug metabolism, influencing drug clearance, efficacy, and potential toxicity.
    Species differences: Variations in enzyme systems across species can cause disparities in drug metabolism. For instance, humans may metabolize certain drugs faster than rodents, altering therapeutic effects.
    Strain differences: Genetic variations within a species can result in differing enzyme activity, impacting drug response and toxicity. For example, some mouse strains may...
    107
    Drug Absorption: Factors Affecting GI Absorption01:19

    Drug Absorption: Factors Affecting GI Absorption

    The process of oral drug absorption can be influenced by several factors. Weakly acidic drugs tend to be absorbed more readily from the stomach due to their nonionized state. However, absorption may be less efficient in the upper intestine, where drugs are often ionized. Interestingly, despite the stomach's apparent advantage for drug absorption, its mucous layer can hinder diffusion. Its surface area is also smaller than the intestine's, which can further slow down the absorption rate.
    3.8K
    Factors Influencing Drug Absorption: Disease States and Pharmacology01:25

    Factors Influencing Drug Absorption: Disease States and Pharmacology

    Multiple disease states can significantly influence the oral drug absorption process by affecting blood flow and the functionality of the gastrointestinal (GI) system. Various GI diseases, including conditions that alter GI motility, such as diarrhea, decreased acid secretions (achlorhydria), and infections, have been associated with reduced drug absorption.
    Substances such as alcohol and specific drugs, including antineoplastics, can also negatively impact drug absorption. For instance,...
    428
    Drug Biotransformation: Overview01:28

    Drug Biotransformation: Overview

    Biotransformation, also known as drug metabolism, is a vital physiological process that chemically alters drugs, facilitating their elimination from the body and terminating their action. This process involves two main phases: phase I and phase II reactions. Phase I reactions, including oxidation, reduction, and hydrolysis, introduce or unmask polar functional groups on the drug molecule, thereby increasing its water solubility. By enhancing water solubility, the drug becomes more hydrophilic...
    331