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使用纵向临床体重指数对儿童肥胖的分类及其验证
Vidhu Thaker1, Nia Ebrahim2, Apurva Khadegi2
1Columbia University Irving Medical Center.
Research square
|January 7, 2025
概括
使用纵向体重指数 (BMI) 数据的儿童肥胖症分类比横截面措施更好地预测长期心脏代谢风险. 这种方法有助于针对儿童持续肥胖的有针对性的干预措施.
科学领域:
- 儿科 儿科 儿科
- 心脏病学 心脏病学
- 公共卫生 公共卫生
背景情况:
- 儿童肥胖与长期心脏代谢风险有关.
- 目前的肥胖症分类依赖于横截面的身体质量指数 (BMI),可能低估了风险.
- 需要改进的方法来分类儿童肥胖及其相关的健康结果.
研究的目的:
- 开发和验证使用纵向临床数据的儿童肥胖症分类系统.
- 评估纵向BMI分类与心脏代谢风险之间的关联.
- 为了比较纵向与横截面BMI分类对不良健康结果的预测能力.
主要方法:
- 一项使用来自第三级医院的电子健康记录数据的观察性研究,在独立队列中进行复制.
- 基于中位数BMI百分位数和持续性肥胖类别的长度分类,用于BMI测量≥3个个体.
- 对纵向BMI类别,早期肥胖,社会经济地位 (SES) 和心脏代谢风险之间的关联进行分析.
主要成果:
- 肥胖 (BMI ≥95百分位数) 影响24.1%的儿童,严重肥胖10.6%.
- 早期发病的肥胖 (≤6年) 与持续性或更高的肥胖类相关.
- 纵向BMI分类显示,与横截面BMI (75.8%) 相比,预测心脏代谢风险的曲线下面面积 (AUC) 更高 (80.0%).
结论:
- 纵向的BMI分类提供了更准确的反映儿童的长期心脏代谢风险.
- 这种精细的分类系统可以指导有针对性的干预策略.
- 它还可能有助于识别可能受益于肥胖相关疾病遗传检测的儿童.
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