中度/重度COVID-19患者中的维生素D补充剂和死亡率:随机对照试验的元分析
Hyder Mirghani1, Shamina Begum2
1Department of Internal Medicine, Faculty of Medicine, University of Tabuk, Tabuk, Saudi Arabia.
概括
补充维生素D似乎不会影响COVID-19患者的死亡率. 这次元分析发现,在COVID-19患者的维生素D摄入量和生存结果之间没有显著的关联.
科学领域:
- 医学研究 医学研究
- 营养科学 营养科学
- 传染性疾病 传染性疾病
背景情况:
- 维生素D缺乏与严重的COVID-19结局有关.
- 维生素D补充剂对COVID-19死亡率的影响仍在争论中.
- 现有研究提出了关于维生素D在COVID-19预后中的作用的相互矛盾的证据.
研究的目的:
- 调查COVID-19患者维生素D补充和死亡率之间的关联.
- 分析不同维生素D剂量对COVID-19生存的影响.
- 为了澄清维生素D在COVID-19结果中的有争议的作用.
主要方法:
- 在六个数据库中进行了系统的文献搜索,截至2023年7月.
- 包括14项随机对照试验 (RCT),涉及COVID-19患者和维生素D补充剂.
- 提取的数据包括维生素D剂量,患者人口统计,死亡率和并发症;使用RevMan 5.4.4进行分析.
主要成果:
- 在维生素D补充和COVID-19死亡率之间没有发现统计学意义上的关联 (OR,1.16;95% CI,0.84-1.59;P=0.36).
- 在高剂量和低剂量维生素D补充剂之间没有观察到死亡率的显著差异 (OR,0.65;95% CI,0.37-1.57;P=0.13).
- 亚分析显示,低剂量补充剂与安慰剂或维生素D缺乏症患者的死亡率没有显著差异.
结论:
- 维生素D补充剂在COVID-19患者中与死亡率没有明显的关联,无论剂量或基线维生素D状态如何.
- 需要进一步的研究来确定最佳的时间和维生素D补充剂的频率COVID-19.
- 目前的证据不支持维生素D补充剂仅用于降低COVID-19死亡率.
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