我们是否可以预测休息期低皮质血清症的狗的低 adrenocorticism? 一个基于临床,血液学和生化变量的预测模型
Nuno Sousa Santos1, Tiago Dias Domingues2, Antonio Maria Tardo3
1Faculty of Veterinary Medicine, University of Lisbon, Lisbon, Portugal.
Frontiers in veterinary science
|January 7, 2025
概括
在患有低静止皮质醇的狗中,厌食症,嗜睡,低白蛋白和低含量表明皮质上腺下降 (HA). 这种模型有助于兽医在临床实践中更准确地诊断HA.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 内分泌学 在内分泌学.
- 狗的健康 狗的健康
背景情况:
- 静止皮质醇度 (RC) 超过2.0μg/dL通常用于排除低上皮质 (HA).
- 患有HA的狗和患有其他疾病的狗的RC水平之间存在显著的重叠.
- 需要更好的HA诊断指标.
研究的目的:
- 使用临床,血液学和生物化学变量开发低皮质 (HA) 的预测模型.
- 为了提高HA的诊断准确度,在呈现低皮质素血症的狗中.
主要方法:
- 一项对92只RC<2.0μg/dL的狗进行回顾性队列研究,并进行上皮质激素刺激试验 (ACTHst).
- 根据ACTH的结果,狗被分为HA和非HA组.
- 用单变量和多变量逻辑回归分析来构建一个预测模型.
主要成果:
- 其中32.2%的狗被诊断出低皮皮质 (HA).
- 厌食症,昏迷,肌素,BUN,ALT和的升高,以及白蛋白,和Na/K比率的降低,在HA组中更为普遍.
- 一个预测模型确定了嗜,厌食症,白蛋白和作为HA的显著预测因素.
结论:
- 在患有休息性低皮质血症的狗中,厌食症,昏迷,低蛋白和低度的组合应该增加对低皮质皮质 (HA) 的怀疑.
- 鉴定的变量可以帮助临床医生在兽医实践中诊断HA.
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