在创伤和烧伤中探索RNA结合蛋白的研究重点
Sujie Xie1, Yifan Liu2, Wei Zhang1
1Department of Burn Surgery, The First Affiliated Hospital of Naval Medical University, People's Republic of China, Research Unit of Key Techniques for Treatment of Burns and Combined Burns and Trauma Injury, Chinese Academy of Medical Sciences, No. 168 Changhai Road, Shanghai 200433, China.
Analytical cellular pathology (Amsterdam)
|January 7, 2025
概括
RNA结合蛋白 (RBPs) 是创伤和烧伤反应的关键. 研究强调它们在伤害机制和伤口愈合中的作用,为更好的患者结果提供了洞察力.
科学领域:
- 生物化学 生物化学
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
背景情况:
- 创伤和烧伤代表着全球重大健康挑战,导致死亡率和发病率.
- RNA结合蛋白 (RBPs) 是基因表达的关键调节者,影响细胞RNA处理和功能.
- 了解RBPs的作用对于推进创伤和烧伤护理治疗策略至关重要.
研究的目的:
- 在创伤和烧伤的背景下,审查有关RNA结合蛋白 (RBPs) 的新兴趋势和关键研究领域.
- 确定与伤害和愈合相关的RBP研究中的当前热点和未来方向.
- 提供关于创伤和烧伤中RBPs的科学文献的文献计和主题分析.
主要方法:
- 手动审查相关文章,并从Web of Science核心集合中检索出版物.
- 使用R-bibliometrix,VOSviewer和CiteSpace.Space进行图书法测量分析.
- 根据PRISMA指南对选定的研究进行的元分析,重点关注RBP表达和患者的结果.
主要成果:
- 在2000年至2024年期间,共确定了539份出版物,其中中国是领先的国家.
- 关键词和主题分析揭示了关键主题,包括"RNA结合蛋白"",创伤性脑损伤"和"炎症".
- 对四项研究 (5,976名患者) 的分析表明,RBP水平与创伤性脑损伤 (TBI) 的预后不佳之间存在相关性.
结论:
- 本综述强调了两个主要的研究热点:创伤伤害病理生理学中的RBPs及其在皮肤伤口愈合中的作用.
- 这些发现为创伤和烧伤护理RBP研究的发展趋势提供了宝贵的见解.
- 这个领域为科学研究人员和临床从业人员在改善患者管理方面提供了重要的参考点.
相关概念视频
Types of RNA
62.5K
Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
62.5K
RNA Stability
32.9K
Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
32.9K
Burn Injuries
2.3K
Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
2.3K
RNA Editing
8.8K
RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
8.8K
Riboswitches
7.9K
Riboswitches are non-coding mRNA domains that regulate the transcription and translation of downstream genes without the help of proteins. Riboswitches bind directly to a metabolite and can form unique stem-loop or hairpin structures in response to the amount of the metabolite present. They have two distinct regions – a metabolite-binding aptamer and an expression platform.
The aptamer has high specificity for a particular metabolite which allows riboswitches to specifically regulate...
The aptamer has high specificity for a particular metabolite which allows riboswitches to specifically regulate...
7.9K
Nucleic Acids
42.9K
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
42.9K


