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Updated: May 7, 2025

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慢性尼古丁暴露会诱导与情绪和焦虑障碍相关的分子和转录性内类型在脑器官神经发育模型中

Emma K Proud1,2,3, Mar Rodríguez-Ruiz1,2,3, Dana M Gummerson1,2,3

  • 1Addiction Research Group, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada.

Frontiers in pharmacology
|January 7, 2025
PubMed
概括

产前尼古丁暴露会扰乱胎儿大脑的发育,导致长期的情绪和焦虑问题. 这项研究使用人类器官来模拟这些效应,以揭示分子和转录组变化.

关键词:
焦虑是一种焦虑.抑郁 抑郁症 抑郁症 抑郁症 抑郁症人类大脑有机体产前发育 产前发育在产前暴露于尼古丁的暴露.

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Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...
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