在高负担国家的青少年的护理连续中,艾滋病毒干预措施:系统性审查和元分析
Yusha Tao1,2, Margaret Byrne3, Dorian Ho4
1University of North Carolina Project-China, Guangzhou, China.
EClinicalMedicine
|January 7, 2025
概括
在高负担国家,一些干预措施改善了青少年艾滋病毒的结果. 资产建设,差异化服务提供,财务激励和数字工具增强了青少年的测试,保留,坚持和病毒抑制.
科学领域:
- 公共卫生 公共卫生
- 实施科学 实施科学
- 青少年健康 青少年健康
背景情况:
- 青少年在艾滋病毒治疗连续性中面临重大挑战,导致高死亡率和发病率.
- 本系统性审查和元分析重点关注艾滋病毒高负担环境中青少年的干预措施.
研究的目的:
- 系统地审查和分析改善青少年艾滋病毒结果的干预措施.
- 确定艾滋病毒预防到治疗级联的有效策略.
主要方法:
- 在PubMed,EMBASE,Scopus和Cochrane图书馆进行了搜索 (2015年1月至2024年9月).
- 包括来自37个高负担国家的99项研究 (57个RCT,42个非RCT).
- 使用随机效应的元分析,将干预对艾滋病毒结果和社会/心理健康的影响汇集在一起.
主要成果:
- 资产建设干预措施改善了艾滋病毒检测的普及率 (RR: 1.38).
- 差异化服务提供改善了ART保留 (RR: 1.18) 和病毒抑制 (RR: 1.19).
- 财政激励提高了对ART的坚持 (RR: 1.52),数字干预增加了对艾滋病毒的测试 (RR: 1.79).
- 青少年中度至实质性参与对艾滋病毒检测产生了更强烈的影响 (RR: 2.37).
结论:
- 基于证据的干预措施可以显著改善青少年艾滋病毒的结果.
- 调查结果支持在高负担国家为青少年艾滋病毒护理制定政策.
- 由于异质性和有限的研究,证据的强度中等至低.
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